 | Morphostasis (tissue homeostasis) is
discussed. |
| Morphostasis must encompass: |
| Intracellular and molecular biology
|
| Cell-to-cell communication and
co-operation (gap junctions in particular) |
| Embryo:-
 | Development from zygote to mature
animal |
| Evolution from simple metazoans to
mammals |
|
| The general scheme of morphostasis
including:-
| The surveillance for sick cells
|
| Cell and animal senescence |
| Malignancy |
| The changing susceptibility to various
diseases with ageing |
| The renewal of sick cells and tissues
|
|
| Basic pathological mechanisms
|
| Immunity:-
| Innate |
| Anamnestic |
| Immune ontogeny |
| Immune phylogeny (from simple metazoans
to mammals) |
| It should also highlight how metazoan
homeostasis and defence diverged as plants split from animals. |
|
| It outlines the importance of the "zygote
derived colony" |
| It introduces the concept of
healthy-self-cells and other-than-healthy-self-cells and their discrimination
|
| It explores the role of gap junctions in
healthy-self expression |
| It explores internal cell surveillance,
apoptosis, necrosis and inflammation |
| It explores the (probable) step by step
evolution or morphostasis |
| It introduces the concept of evolutionary
shells |
| It explores the pivotal role of natural
killer cells in the switch to an anamnestic (memorising) immune process.
|
| It explores the "clinical consequences"
of these points. |
